KPV
10mg · 2ml
SKU: kpv-10mg
KPV is a naturally occurring tripeptide derived from alpha-melanocyte-stimulating hormone (a-MSH) that binds to melanocortin receptors to suppress pro-inflammatory cytokines including TNF-a, IL-1B, and IL-6. It calms inflammation across the gut, skin, and cellular level, supporting intestinal barrier integrity, wound healing, and immune balance.
Product Specifications
Strength
10mg
Volume / Qty
2ml
Form
Lyophilized Powder
Suggested Retail Price
$136.00
Dosing Guide
Recommended Dose
200-500 mcg daily
Route
Subcutaneous, oral, or topical
Frequency
Daily (varies by route)
Clinician Access Required
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KPV is available exclusively to verified clinicians under IRB-approved research protocol PPRN-001-2025.
IRB-Approved Research Protocol
PPRN-001-2025 ·IRCM-2025-467
Approved December 3, 2025 · Principal Investigator: Dr. M. Scott Mortensen, MD, MPAS, MLT
Save up to 80% with the 10,000 Growth Bundle
KPV is included in this clinic-tier package. Bundle includes higher volume in weight loss, mitochondrial health, longevity, and tissue repair with 1 free Tirz 15mg + 1 free Reta 15mg as a bonus.
For Clinicians
Clinical Reference
Pharmacology, safety, monitoring, and dosing reference for KPV. Always individualize based on patient context.
Mechanism of Action
Receptor / Target
C-terminal tripeptide of α-MSH; modulates melanocortin and NF-κB pathways
Half-Life
~30 minutes
Onset of Action
1–2 weeks for anti-inflammatory effects
Metabolism
Hepatic and renal proteolysis
Cautions & Contraindications
Contraindicated In
- Hypersensitivity to KPV
- Pregnancy and lactation
Use Caution With
- Limited long-term safety data
- Co-administered with mast cell stabilizers in IBD protocols
Suggested Labs to Monitor
hs-CRP, fecal calprotectin (if GI use)
Baseline / 8 weeksCBC, CMP
Baseline / 12 weeksLab interpretation guidance comes from peer-reviewed literature. Always individualize based on patient context.
Reconstitution Calculator
Calculate exactly how many units to draw on a U-100 insulin syringe for your target dose. Pre-filled with KPV defaults — adjust as needed.
Total peptide in the vial (e.g. 10mg)
Volume of BAC water used to reconstitute
Single-injection dose in micrograms
Draw to
Per mL
5000 mcg
Doses per vial
~40
Always double-check reconstitution math. This tool is for reference — clinician supervision required.
Plumb DISCOVER
What KPV targets
Patient goals, biomarkers, and wearable signals this peptide addresses. Powers the future Plumb AI protocol engine.
Patient Goals
Biomarkers Tracked
Clinical Synergy
Frequently stacked with KPV
Peptides commonly combined with KPV for synergistic clinical outcomes.
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KPV is a naturally occurring tripeptide derived from alpha-melanocyte-stimulating hormone (a-MSH) that binds to melanocortin receptors to suppress pro-inflammatory cytokines including TNF-a, IL-1B, and IL-6. It calms inflammation across the gut, skin, and cellular level, supporting intestinal barrier integrity, wound healing, and immune balance.
View Details