NAD+ Cellular Energy Restoration Protocol

What This Protocol Is For

This protocol is designed to help your cells make energy more efficiently. NAD+ is a molecule your body already uses every second of every day to turn food into fuel, repair damaged DNA, and keep your brain and nervous system running smoothly. The trouble is that your natural NAD+ levels drop as you get older — and stress, illness, heavy drinking, and certain medications can drain them even faster.

Your doctor is recommending this protocol because you're looking for one or more of these results: steadier daytime energy, sharper focus and memory, better recovery from workouts or illness, improved mood, or support during recovery from alcohol or substance use. Some patients also use it as part of a broader anti-aging or "healthspan" plan.

Think of this as refilling a tank that's been running low. When your cells have enough NAD+ to work with, a lot of small things tend to get better at once.

What You'll Be Taking

• NAD+ (1000 mg) — the "loading dose." This is the higher dose used at the start to refill your stores quickly. You'll typically use this during your first few weeks.
• NAD+ (500 mg) — the "maintenance dose." This is the lower dose used to keep your levels topped off once the loading phase is done. You'll typically use this on an ongoing weekly or twice-weekly basis.

Your doctor will tell you whether you're doing IV infusions in the office, at-home injections under the skin (called subcutaneous, or "SC"), or a combination of both.

How to Use It

If you're getting IV infusions in the office:

• Plan on 60–120 minutes per visit. NAD+ has to be given slowly — pushing it faster causes chest tightness and nausea, so the nurse will dial the drip to your comfort.
• Eat a normal meal beforehand and bring water. Some people feel wiped out right after; others feel great. Don't plan anything stressful for the rest of the day.

If you're doing at-home SC injections:

• Your medication will arrive either pre-mixed or as a powder that needs to be mixed with sterile water (this is called reconstitution). If it's a powder, ask the office to walk you through mixing it the first time — it takes 2 minutes and you only need to learn it once.
• Inject into the fat of your belly or upper thigh, rotating sites each time so you don't get sore in one spot.
• Go slowly. NAD+ can sting going in; injecting over 30–60 seconds helps a lot.
• Best time of day: morning or early afternoon. NAD+ can be stimulating, and a late-day dose may keep you up.
• Food: doesn't matter — take it with or without.
• Storage: keep your vial in the refrigerator. Don't freeze it.
• Missed a dose? Just take it the next day and get back on your schedule. Don't double up.

What to Expect

• Week 1: You may feel a noticeable energy lift after your first dose or two — or you may feel tired as your body adjusts. Both are normal. Sleep can shift in the first week.
• Week 4: Most people notice steadier daytime energy, less of an afternoon crash, and clearer thinking. Mood often feels more even.
• Week 8: Recovery from exercise, stress, or poor sleep tends to feel faster. Some people notice better stamina and motivation. If you're using this as part of addiction recovery support, cravings often feel quieter by this point.
• Week 12: This is when the deeper benefits show up — sharper focus, better resilience, and a general sense of running on a fuller tank. Give it the full 12 weeks before deciding how well it's working for you.

Results vary. Some people feel a dramatic difference; others feel a quieter, steadier improvement. Both count.

Common Side Effects

• Flushing, chest pressure, or a "rushing" feeling during the dose. This is the most common one and it almost always means the dose is going in too fast. Slow down your injection or ask the nurse to slow your IV drip. It passes within a few minutes.
• Nausea or upset stomach. Usually mild. Eating a light snack before your dose and slowing the injection helps. Typically settles within the first 1–2 weeks.
• Headache. Drink extra water on dose days. Usually goes away as your body adjusts.
• Trouble sleeping if dosed too late in the day. Move your dose to the morning.
• Soreness or a small bump at the injection site (for SC dosing). Rotate sites and apply a warm compress. Should fade within a day.

Most side effects are mild and settle within the first couple of weeks as your body gets used to the protocol.

When to Call the Office

Stop dosing and call us if you notice any of the following:

• Chest pain or pressure that doesn't go away when the dose is finished
• Shortness of breath or trouble breathing
• A racing or irregular heartbeat
• Severe headache that won't quit
• Fainting or feeling like you might pass out
• A rash, hives, or swelling of the face, lips, or tongue
• An injection site that becomes red, hot, swollen, or starts draining

If any of these feel severe or get worse fast, call 911 first, then let us know.

A Note About This Protocol

NAD+ therapy is supervised through Peptide Pure's research network and is not FDA-approved for the uses described here — your doctor is prescribing it based on a growing body of clinical experience and monitoring your response closely. It's a powerful tool, but it works best alongside the basics: good sleep, real food, movement, and managing stress. It is not a substitute for them.

Questions for Your Next Visit

• How will we know this is working for me — are there specific lab markers or symptoms we should track?
• Once I finish the loading phase, what does my long-term maintenance dose look like?
• Are there supplements (like NMN, NR, or methyl donors) that would pair well with this, or any I should avoid?
• Based on my goals, should we consider adding or layering another peptide protocol down the road?