MOTS-c
40mg · 2ml
SKU: mots-c-40mg
MOTS-c is a naturally occurring mitochondrial-derived peptide that regulates metabolism and cellular stress responses by activating AMPK, a key cellular energy regulator. It improves glucose uptake, fat oxidation, insulin sensitivity, and exercise performance while reducing oxidative stress and inflammation.
Available Options
Product Specifications
Strength
40mg
Volume / Qty
2ml
Form
Lyophilized Powder
Suggested Retail Price
$330.00
Dosing Guide
Recommended Dose
5-10 mg
Route
Subcutaneous
Frequency
3-5x weekly
Clinician Access Required
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MOTS-c is available exclusively to verified clinicians under IRB-approved research protocol PPRN-001-2025.
IRB-Approved Research Protocol
PPRN-001-2025 ·IRCM-2025-467
Approved December 3, 2025 · Principal Investigator: Dr. M. Scott Mortensen, MD, MPAS, MLT
Save up to 80% with the 5,000 Foundation Bundle
MOTS-c is included in this clinic-tier package. Bundle includes weight loss (tirz & reta) + longevity/repair (mots-c, ghk-cu, bpc-157, epithalon) with 1 free Tirz 15mg as a bonus.
For Clinicians
Clinical Reference
Pharmacology, safety, monitoring, and dosing reference for MOTS-c. Always individualize based on patient context.
Mechanism of Action
Receptor / Target
Mitochondrial-derived peptide; modulates AMPK, folate cycle, and metabolic stress response
Half-Life
~30–60 minutes
Onset of Action
2–4 weeks for metabolic effects
Metabolism
Renal and hepatic proteolysis
Cautions & Contraindications
Contraindicated In
- Pregnancy and lactation
- Hypersensitivity to MOTS-c
Use Caution With
- Hypoglycemia risk in insulin-treated diabetics
- May enhance exercise tolerance — adjust training load
Suggested Labs to Monitor
HbA1c, fasting glucose, fasting insulin
Baseline / 12 weeksMOTS-c improves insulin sensitivity.
Lipid panel
Baseline / 12 weekshs-CRP
Baseline / 12 weeksLab interpretation guidance comes from peer-reviewed literature. Always individualize based on patient context.
Reconstitution Calculator
Calculate exactly how many units to draw on a U-100 insulin syringe for your target dose. Pre-filled with MOTS-c defaults — adjust as needed.
Total peptide in the vial (e.g. 10mg)
Volume of BAC water used to reconstitute
Single-injection dose in micrograms
Draw to
Per mL
20000 mcg
Doses per vial
~160
Always double-check reconstitution math. This tool is for reference — clinician supervision required.
Plumb DISCOVER
What MOTS-c targets
Patient goals, biomarkers, and wearable signals this peptide addresses. Powers the future Plumb AI protocol engine.
Patient Goals
Biomarkers Tracked
Wearable Signals
Essential Protocol Packages
MOTS-c is part of 3 clinical protocols
Bundle this peptide with synergistic compounds at clinic-tier pricing.
Metabolic Health & Body Composition Comparison Protocol
Compare GLP-1/GIP agonists alongside metabolic peptides for body composition optimization.
Metabolic & Mitochondrial Support Protocol
Mitochondrial-targeted peptides for cellular energy, metabolic optimization, and longevity.
Longevity Protocol
Comprehensive anti-aging and longevity protocol targeting telomeres, senescence, and mitochondrial health.
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