NAD+
500mg · 5ml
SKU: nad-500mg
NAD+ (nicotinamide adenine dinucleotide) is a vital coenzyme present in all living cells, participating in over 500 enzymatic reactions essential for energy metabolism and cellular function. It supports DNA repair and gene regulation by serving as a substrate for sirtuins and PARPs, enzymes that regulate aging, stress resistance, and genomic stability.
Available Options
Product Specifications
Strength
500mg
Volume / Qty
5ml
Form
Lyophilized Powder
Suggested Retail Price
$100.00
Dosing Guide
Recommended Dose
50-100 mg per dose
Route
Varies by clinician
Frequency
1-3x weekly
Clinician Access Required
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NAD+ is available exclusively to verified clinicians under IRB-approved research protocol PPRN-001-2025.
IRB-Approved Research Protocol
PPRN-001-2025 ·IRCM-2025-467
Approved December 3, 2025 · Principal Investigator: Dr. M. Scott Mortensen, MD, MPAS, MLT
Save up to 80% with the 5,000 Foundation Bundle
NAD+ is included in this clinic-tier package. Bundle includes weight loss (tirz & reta) + longevity/repair (mots-c, ghk-cu, bpc-157, epithalon) with 1 free Tirz 15mg as a bonus.
For Clinicians
Clinical Reference
Pharmacology, safety, monitoring, and dosing reference for NAD+. Always individualize based on patient context.
Mechanism of Action
Receptor / Target
Coenzyme; substrate for sirtuins (SIRT1-7), PARPs, and CD38
Half-Life
Variable; intracellular pool replenishment within hours
Onset of Action
Energy and cognition within 1–2 weeks
Metabolism
Hydrolyzed and recycled via salvage pathway
Cautions & Contraindications
Contraindicated In
- Hypersensitivity to NAD+ or excipients
- Pregnancy and lactation (insufficient safety data)
Use Caution With
- Active malignancy (NAD+ supports both healthy and malignant cell metabolism)
- Slow infusion to avoid flushing, nausea, and chest tightness
- May interact with chemotherapy (PARP inhibitor pathway)
Suggested Labs to Monitor
CBC, CMP
Baseline / 12 weeksMethylation panel (homocysteine, B12, folate)
Baseline / 12 weeksNAD+ metabolism interacts with methylation cycles.
hs-CRP
Baseline / 12 weeksLab interpretation guidance comes from peer-reviewed literature. Always individualize based on patient context.
Reconstitution Calculator
Calculate exactly how many units to draw on a U-100 insulin syringe for your target dose. Pre-filled with NAD+ defaults — adjust as needed.
Total peptide in the vial (e.g. 10mg)
Volume of BAC water used to reconstitute
Single-injection dose in micrograms
Draw to
Per mL
100000 mcg
Doses per vial
~2000
Always double-check reconstitution math. This tool is for reference — clinician supervision required.
Plumb DISCOVER
What NAD+ targets
Patient goals, biomarkers, and wearable signals this peptide addresses. Powers the future Plumb AI protocol engine.
Patient Goals
Biomarkers Tracked
Wearable Signals
Peptide Buzz™
FXN Energy Strip
Coming soon to Peptide Buzz
Daily Wellness Alternative
Prefer a daily product over injection?
Sublingual NAD+ precursor strips for daily mitochondrial energy support.
Essential Protocol Packages
NAD+ is part of 3 clinical protocols
Bundle this peptide with synergistic compounds at clinic-tier pricing.
Neuroplasticity & Circadian Optimization Protocol
Neuroendocrine support for circadian rhythm, neuroplasticity, and cognitive resilience.
Metabolic & Mitochondrial Support Protocol
Mitochondrial-targeted peptides for cellular energy, metabolic optimization, and longevity.
Longevity Protocol
Comprehensive anti-aging and longevity protocol targeting telomeres, senescence, and mitochondrial health.
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