RETA
20mg · 2ml
SKU: RT-20mg
Retatrutide is a synthetic triple agonist peptide engineered to activate glucagon, GLP-1, and GIP receptors simultaneously. It reduces appetite, slows gastric emptying, improves blood glucose regulation, and enhances energy expenditure through multiple complementary metabolic pathways.
Available Options
Product Specifications
Strength
20mg
Volume / Qty
2ml
Form
Lyophilized Powder
Suggested Retail Price
$280.00
Dosing Guide
Recommended Dose
1.0 mg starting, once weekly
Route
Subcutaneous
Frequency
Once weekly
Clinician Access Required
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RETA is available exclusively to verified clinicians under IRB-approved research protocol PPRN-001-2025.
IRB-Approved Research Protocol
PPRN-001-2025 ·IRCM-2025-467
Approved December 3, 2025 · Principal Investigator: Dr. M. Scott Mortensen, MD, MPAS, MLT
Save up to 80% with the 5,000 Foundation Bundle
RETA is included in this clinic-tier package. Bundle includes weight loss (tirz & reta) + longevity/repair (mots-c, ghk-cu, bpc-157, epithalon) with 1 free Tirz 15mg as a bonus.
For Clinicians
Clinical Reference
Pharmacology, safety, monitoring, and dosing reference for RETA. Always individualize based on patient context.
Mechanism of Action
Receptor / Target
Triple agonist of GLP-1, GIP, and glucagon receptors
Half-Life
~6 days (weekly dosing)
Onset of Action
Appetite suppression within days; weight loss 4–8 weeks
Metabolism
Proteolytic cleavage; renal and hepatic clearance
Cautions & Contraindications
Contraindicated In
- Personal or family history of medullary thyroid carcinoma
- MEN-2 syndrome
- Pregnancy and lactation
- Hypersensitivity to retatrutide
Use Caution With
- Pancreatitis history
- Severe gastroparesis
- Diabetic retinopathy
- Glucagon agonism may transiently raise glucose — monitor closely in diabetics
- Higher GI side effect rate than TIRZ/SEMA — titrate slowly
Suggested Labs to Monitor
HbA1c, fasting glucose
Baseline / 12 weeksLipase and amylase
Baseline / as symptoms warrantLipid panel
Baseline / 12 weeksCMP (liver enzymes)
Baseline / 12 weeksGlucagon agonism may affect hepatic glucose handling.
Lab interpretation guidance comes from peer-reviewed literature. Always individualize based on patient context.
Reconstitution Calculator
Calculate exactly how many units to draw on a U-100 insulin syringe for your target dose. Pre-filled with RETA defaults — adjust as needed.
Total peptide in the vial (e.g. 10mg)
Volume of BAC water used to reconstitute
Single-injection dose in micrograms
Draw to
Per mL
10000 mcg
Doses per vial
~80
Always double-check reconstitution math. This tool is for reference — clinician supervision required.
Plumb DISCOVER
What RETA targets
Patient goals, biomarkers, and wearable signals this peptide addresses. Powers the future Plumb AI protocol engine.
Patient Goals
Biomarkers Tracked
Wearable Signals
Essential Protocol Packages
RETA is part of 1 clinical protocol
Bundle this peptide with synergistic compounds at clinic-tier pricing.
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