TIRZ
10mg · 2ml
SKU: TZ-10mg
Tirzepatide is a synthetic dual GIP/GLP-1 receptor agonist that simultaneously activates both glucose-dependent insulinotropic polypeptide and glucagon-like peptide-1 pathways. This dual action reduces hunger, slows digestion, stabilizes blood sugar, and promotes long-term metabolic improvements including weight loss and improved body composition.
Product Specifications
Strength
10mg
Volume / Qty
2ml
Form
Lyophilized Powder
Suggested Retail Price
$150.00
Dosing Guide
Recommended Dose
1.5 mg starting, once weekly
Route
Subcutaneous
Frequency
Once weekly
Clinician Access Required
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TIRZ is available exclusively to verified clinicians under IRB-approved research protocol PPRN-001-2025.
IRB-Approved Research Protocol
PPRN-001-2025 ·IRCM-2025-467
Approved December 3, 2025 · Principal Investigator: Dr. M. Scott Mortensen, MD, MPAS, MLT
Save up to 80% with the 5,000 Foundation Bundle
TIRZ is included in this clinic-tier package. Bundle includes weight loss (tirz & reta) + longevity/repair (mots-c, ghk-cu, bpc-157, epithalon) with 1 free Tirz 15mg as a bonus.
For Clinicians
Clinical Reference
Pharmacology, safety, monitoring, and dosing reference for TIRZ. Always individualize based on patient context.
Mechanism of Action
Receptor / Target
Dual agonist of GIP and GLP-1 receptors
Half-Life
~5 days (allows weekly dosing)
Onset of Action
Appetite suppression within days; weight loss 4–12 weeks
Metabolism
Proteolytic cleavage; renal and hepatic clearance
Cautions & Contraindications
Contraindicated In
- Personal or family history of medullary thyroid carcinoma
- Multiple Endocrine Neoplasia syndrome type 2 (MEN-2)
- Pregnancy and lactation
- Hypersensitivity to tirzepatide
Use Caution With
- Pancreatitis history (acute and chronic)
- Severe gastroparesis or delayed gastric emptying
- Diabetic retinopathy (rapid glycemic improvement may worsen)
- Suicidal ideation history (ongoing FDA monitoring of GLP-1 class)
- Gallbladder disease
- Titrate slowly to minimize GI side effects
Suggested Labs to Monitor
HbA1c
Baseline / 12 weeksPrimary glycemic efficacy marker.
Fasting glucose, fasting insulin
Baseline / 12 weeksLipase and amylase
Baseline / as symptoms warrantScreen for pancreatitis, especially with abdominal symptoms.
Lipid panel
Baseline / 12 weeksTIRZ improves triglycerides and may improve overall lipid profile.
Calcitonin (if family history of MTC)
Baseline onlyLab interpretation guidance comes from peer-reviewed literature. Always individualize based on patient context.
Reconstitution Calculator
Calculate exactly how many units to draw on a U-100 insulin syringe for your target dose. Pre-filled with TIRZ defaults — adjust as needed.
Total peptide in the vial (e.g. 10mg)
Volume of BAC water used to reconstitute
Single-injection dose in micrograms
Draw to
Per mL
5000 mcg
Doses per vial
~40
Always double-check reconstitution math. This tool is for reference — clinician supervision required.
Plumb DISCOVER
What TIRZ targets
Patient goals, biomarkers, and wearable signals this peptide addresses. Powers the future Plumb AI protocol engine.
Patient Goals
Biomarkers Tracked
Wearable Signals
Essential Protocol Packages
TIRZ is part of 1 clinical protocol
Bundle this peptide with synergistic compounds at clinic-tier pricing.
Clinical Synergy
Frequently stacked with TIRZ
Peptides commonly combined with TIRZ for synergistic clinical outcomes.
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TIRZ 15mg (Lead Time)
Tirzepatide is a synthetic dual GIP/GLP-1 receptor agonist that simultaneously activates both glucose-dependent insulinotropic polypeptide and glucagon-like peptide-1 pathways. This dual action reduces hunger, slows digestion, stabilizes blood sugar, and promotes long-term metabolic improvements including weight loss and improved body composition.
View Details